EPO is a natural source of the important omega-6 fatty acid gamma-linolenic acid (GLA). Low levels of GLA have been found in women with PMS and adults as well as children with eczema. Evening primrose oil (EPO) is a source of the omega-6 essential fatty acids gamma-linolenic acid (GLA) and linoleic acid (LA). Conditions that involve inflammation, such as eczema, may benefit from supplementation with omega-6 essential fatty acids. Low levels of GLA have been found in women with premenstrual syndrome (PMS). Supplementing with EPO may help with the symptoms of PMS. Lifestyle factors such as excess saturated fats in the diet, ongoing high stress levels, alcohol consumption, and smoking may all affect GLA metabolism, leading to the need for dietary supplementation.